At Notre Dame, fighting cancer is not confined to one discipline. It’s the work of engineers, chemists, biologists, industrial designers, and more.
Cancer Research
Cancer Research
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Researchers from the University of Notre Dame and Stanford University have developed a new approach for cancer immunotherapy that promises to improve efficacy and reduce systemic immune activation toxicity.
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Researchers from the University of Notre Dame have published the first known detailed study of breast cancer tissue from Native American women. The study, published in npj Precision Oncology, reveals important molecular differences that may impact the efficacy of therapies for female, Native American breast cancer patients.
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Notre Dame researchers have created a tiny, wireless LED implant that uses green light to destroy deep-seated tumors. By triggering a specific type of cell death called pyroptosis, this device not only kills cancer cells but also prompts the immune system to join the fight.
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To invade healthy tissues and continue growing, aggressive cancers mimic and circumvent the body’s native piping system of veins and arteries. Through this process, known as vasculogenic mimicry (VM), tumor cells form fluid-conducting channels that transport blood, oxygen, and nutrients directly to the growing tumor. This behavior enables tumor metastasis...
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Organic chemistry has numerous applications in the real world, especially in the realm of medicinal chemistry. Due to the complexity within organic chemistry, there is a great potential for developing molecules with several applications. When he was a child, Pratik Yadav, assistant research professor in the Department of Chemistry and...
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To think, feel, talk and move, neurons send messages through electrical signals in the brain and spinal cord. This intricate communication network is built of billions of neurons connected by synapses and managed and modified by glial cells. When neurons die, this communication network is disrupted and since this loss...
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In the quiet spaces of pediatric oncology, Dr. Christy Lucas ‘16 finds purpose in being a faithful narrator—helping patients and families tell, to the very last pages, the stories they never thought they’d have to write.
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At 10 one-millionths of a meter wide, a single human cell is tiny. But something even smaller exerts an enormous influence on everything a cell does: proton concentration, or pH. On the microscopic level, pH-dependent structures regulate cell movement and division. Altered pH response can accelerate the development of cancers...
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The University of Notre Dame and Beacon Health System have announced a new, multiyear research collaboration. Through this agreement, Notre Dame and Beacon will jointly develop collaborative, health-focused research projects that are of interest to both organizations, particularly in the areas of oncology and health data.
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Any student who has studied abroad will tell you that stepping outside your comfort zone is a necessary part of the process—and worth it. But many of them do so in the company of other students, often even friends, who are in the same program. When Jennifer Leon '27 decided...
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Research from the University of Notre Dame is shedding light on why Black women are likely to have early-onset or more aggressive subtypes of breast cancer. The study published in iScience found that a population of cells in breast tissues, dubbed PZP cells, send cues that prompt behavioral changes that...
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Researchers at the University of Notre Dame have developed a novel, automated device capable of diagnosing glioblastoma, a fast-growing and incurable brain cancer, in less than an hour. The average glioblastoma patient survives 12-18 months after diagnosis.
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Serious quality defects were found in a significant number of cancer medications from sub-Saharan Africa, according to new research from the University of Notre Dame.
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Adding a pre-ketone supplement—a component of a high-fat, low-carb ketogenic diet—to a type of cancer therapy in a laboratory setting was highly effective for treating prostate cancer, researchers from the University of Notre Dame found.
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A study from the University of Notre Dame, Massachusetts General Hospital, and the National Institutes of Health has identified a combination of medications that may improve blood flow within granulomas, benefiting drug delivery. Published in the Proceedings of the National Academy of Sciences, the study leverages decades of cancer...
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A new study links a high body mass index (BMI) to alterations in the structure and environment of cancerous tumors. Most women with ovarian cancer are diagnosed with the most advanced form of the disease. Less than a third of those diagnosed with the disease survive five years later. As...
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In a new study in NPJ Genomic Medicine, researchers at the University of Notre Dame have found that a largely understudied cell could offer new insight into how the aggressive, primary brain cancer is able to resist immunotherapy.
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University of Notre Dame researchers have discovered another way tumor cells transfer genetic material to other cells in their microenvironment, causing cancer to spread.
Video
Siyuan Zhang studies how medications already commonly prescribed can be used to target cancer.
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Article
More than 700 million people lack access to clean water, but research from the University of Notre Dame is helping organizations optimize how they manage, maintain, and build water pumps to reduce water scarcity.
Article
Notre Dame engineer develops vine robot to help first responders after disasters
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Notre Dame researchers are developing AI technology designed to help caregivers interpret the nonverbal communication of people with profound intellectual and multiple disabilities.
Article
At Notre Dame Law School, the Eviction Clinic gives students real-world experience.
Podcast
For seven hours, Notre Dame alumna Kelsey Young ’09 sat in NASA mission control, listening as astronauts described the Moon in real time from a vantage point no human had ever experienced before.